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官方杂志> 皮肤附件源干细胞的细胞生物学及其在创伤修复中的潜在应用
皮肤附件源干细胞的细胞生物学及其在创伤修复中的潜在应用
      来源:Burns & Trauma




REVIEW

Skin appendage-derived stem cells: cell biology and potential for wound repair

引用格式: Xie J, Yao B, Han Y, Huang S, Fu X. Skin appendage-derived stem cells: cell biology and potential for wound repair. Burns & Trauma 2016; 4:38.


表皮和皮肤附件源干细胞对维持皮肤稳态和再生不可或缺,尤其在皮肤损伤后结构和功能恢复中起着重要作用。目前,尽管我们对表皮干细胞已有了一定认识,但对皮肤附件源干细胞的了解还非常有限。


解放军总医院付小兵院士团队在皮肤附件源干细胞的研究方面处于国际领先地位,该团队黄沙教授等学者全面综述了现阶段对皮肤附件源干细胞的认识,包括该类细胞的主要特征、表达的典型生物标志物,以及在创面修复中所发挥的作用,并进一步讨论了当前该类细胞用于损伤修复的研究策略、潜在应用及其局限性,希望能为未来的研究和应用启迪思路。


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Abstract

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and regeneration. These stem cells also participate in the repair of the epidermis after injuries, inducing restoration of tissue integrity and function of damaged tissue. Unlike epidermis-derived stem cells, comprehensive knowledge about skin appendage-derived stem cells remains limited. In this review, we summarize the current knowledge of skin appendage-derived stem cells, including their fundamental characteristics, their preferentially expressed biomarkers, and their potential contribution involved in wound repair. Finally, we will also discuss current strategies, future applications, and limitations of these stem cells, attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.

查看原文Skin appendage-derived stem cells: cell biology and potential for wound repair