Skin tissue engineering advances in severe burns: review and therapeutic applications
Alvin Wen Choong Chua, YikCheong Khoo, Bien Keem Tan, Kok Chai Tan, Chee Liam Foo and Si Jack Chong.
How to cite this article: Chua AWC, Khoo YC, Tan BK,Tan KC, Foo CL, Chong SJ. Skin tissue engineering advances in severe burns: review and therapeutic applications. Burns & Trauma 2016 4:3.
皮肤组织工程技术和产品在烧伤创面处理中扮演越来越重要的角色，但对于大面积特别是深度烧伤的创面处理，当前的技术手段还有很大局限性。Burns & Trauma 最新刊出“Skin tissue engineering advances in severe burns: review and therapeutic applications”一文，详细介绍了各种代表性皮肤组织工程产品的特点和最新进展，并系统综述了皮肤组织工程与其他创面覆盖技术的结合在大面积烧伤治疗方面的应用以及待解决的问题。欢迎访问期刊网站www.burnstrauma.com阅读全文。
Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium (within 3 to 4 weeks) helped alleviate the problem of insufficient donor site for extensive burn, many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn excision. Alternatives offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly successfully. Despite the availability of these commercial products, they all suffer from the same problems of extremely high cost, sub-normal skin microstructure and inconsistent engraftment, especially in full thickness burns. Clinical practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes, usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results long-term. This review seeks to bring the reader through the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.
Burns, Skin tissue engineering, Stem cells, Cultured epithelial autografts, Dermal substitutes, Microskin grafting