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局部注射法治疗瘢痕疙瘩:疗效知多少
      来源:Burns & Trauma

Intralesional injection treatment of hypertrophic scars and keloids: a systematic review regarding outcomes


Aurelia Trisliana Perdanasari1, Matteo Torresetti2, Luca Grassetti2, Fabio Nicoli3, Yi Xin Zhang1*, Talal Dashti4, Giovanni Di Benedetto2 and Davide Lazzeri4

How to cite this article: Trisliana PA, Torresetti M, Grassetti L, Nicoli F, Zhang YX, Dashti T, et al. Burns Trauma 2015, 3:14


Abstract

Background

The aim of this review was to explore the existing body of literature focusing on the intralesional treatments of keloids and hypertrophic scars.

Methods

A comprehensive systematic review of related articles was conducted across multiple databases. Article selection was limited to those published in the English language between 1950 and 2014. Search terms for the on-line research were “scar(s),” “keloid(s),” “hypertrophic,” “injection,” “intralesional,” and “treatment”.

Results

The initial search returned 2548 published articles. After full text review, the final search yielded 11 articles that met inclusion criteria. A total of 14 patient samples in 11 articles were collected. The most frequent intralesional injection treatment studied was triamcinolone (n = 5), followed by bleomycin (n = 3), 5-fluorouracil (n = 2), verapamil (n = 2), cryosurgery, and collagenase. The scar height reduction for all but one study was demonstrated, with acceptable complication and recurrence rate. Only three articles reported a follow-up period longer than 18 months, and only two studies used standardized outcome criteria with a quantitative scale.

Conclusions

Although many treatment options have already been described in the literature, there is no universally accepted treatment resulting in permanent hypertrophic or keloid scar ablation. The lack of adequately long-term powered randomized controlled trials does not permit to establish definitive conclusions with implications for routine clinical practice.

Level of evidence

III/Therapeutic

Keywords:

Intralesional injections; Hypertrophic scar; Keloid; Systematic review; Outcomes